POL Scientific, LLC is an open access publisher specializing in the publication of basic research and medical journals covering a diverse spectrum of life sciences and medicine for the benefit of humanity. Our leading journals include: 1) Journal of Biological Methods (ISSN: 2326-9901), committed to publish innovative biological protocols and techniques; 2) Bladder (ISSN: 2327-2120), a medical journal dedicated to publishing research on bladder biology and disease. We are committed to support the scientific community by publishing impactful research and enhancing communication among scientists. At POL Scientific, we are continuously looking for ways to accelerate scientific progress and to strive for transparency and open communication, making knowledge freely accessible without barrier.
Latest articles from journals we publish
- Getting two birds with one stone: Combining immunohistochemistry and Azan staining in animal morphology September 2, 2021Classical histological stained sections have the disadvantage that fine structures, like individual neurites, or specific macromolecules, like neurotransmitters cannot be visualized. Due to its highly specific staining of only one target molecule within the cell, the visualization of delicate structures, which would be superimposed by other tissue layers in classical Azan staining, is possible with […]Patrick Beckers, Müller Claudia, Christiane Wallnisch, Thomas Bartolomaeus
- A method for the efficient iron-labeling of patient-derived xenograft cells and cellular imaging validation September 2, 2021There is momentum towards implementing patient-derived xenograft models (PDX) in cancer research to reflect the histopathology, tumor behavior, and metastatic properties observed in the original tumor. These models are more predictive of clinical outcomes and are superior to cell lines for preclinical drug evaluation and therapeutic strategies. To study PDX cells preclinically, we used both […]Natasha N. Knier, Veronica P. Dubois, Yuanxin Chen, John A. Ronald, Paula J. Foster
- Tissue-specific DamID protocol using nanopore sequencing August 27, 2021DNA adenine methylation identification (DamID) is a powerful method to determine DNA binding profiles of proteins at a genomic scale. The method leverages the fusion between a protein of interest and the Dam methyltransferase of E. coli, which methylates proximal DNA in vivo. Here, we present an optimized procedure, which was developed for tissue-specific analyses […]Georgina Gómez-Saldivar, Dominique A. Glauser, Peter Meister
- Comparison of CRISPR and adenovirus-mediated Myd88 knockdown in RAW 264.7 cells and responses to lipopolysaccharide stimulation July 15, 2021Genomic manipulation offers the possibility for novel therapies in lieu of medical interventions in use today. The ability togenetically restore missing inflammatory genes will have a monumental impact on our current immunotherapy treatments. This study compared the efficacy of two different genetic manipulation techniques: clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) […]Alexander L. Kolb, Marinaliz Reynoso, Ronald W. Matheny
- Does deep brain stimulation improve Parkinson’s disease-related lower urinary tract symptoms and voiding dysfunction? August 27, 2021Parkinson’s disease (PD), caused by degeneration of dopaminergic neurons, leads to motor and autonomic symptoms. A large proportion of PD patients experience lower urinary tract symptoms (LUTS) and voiding dysfunction, associated with poor quality of life. Deep brain stimulation (DBS) is an adjunctive therapy used in combination with medication for Parkinsonian motor symptoms and is […]